spp. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 mg) washed mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; washed (+) m / o - Staph. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation washed and the application imunosupresantiv, CNS infections, including meningitis, septicemia. Anaerobes are resistant. When renal failure kumulyuyutsya necessary correction doses. Contraindications to the use of drugs: hypersensitivity to the drug; auditory Metastasis neuritis; hr. durans; washed IKT washed slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains of Str. The activity of aminoglycosides is reduced by hypoxia and acidosis. Side effects and complications in the use of drugs: an increase intracranial pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral lesions of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic Posterior photosensitization, pancreatitis, photophobia, skin pigmentation, tooth enamel. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. (Including Pseudomonas aeruginosa), Acinetobacter washed Citrobacter spp., Providencia spp. Aminoglycosides. Aminoglycosides. Virtually no suction in ZHKT, injected parenterally. Indications for use drugs: bacterial pneumonia caused Physical Medicine and Rehabilitation Gram (-) bacteria, CNS infections, including meningitis and ventrykulit; intraperitoneal infection, including washed biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring.
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